Fast computation of minimal elementary decompositions of metabolic flux vectors
نویسندگان
چکیده
منابع مشابه
Fast computation of minimal elementary decompositions of metabolic flux vectors
The concept of elementary flux vector is valuable in a number of applications of metabolic engineering. For instance, in metabolic flux analysis, each admissible flux vector can be expressed as a non-negative linear combination of a small number of elementary flux vectors. However a critical issue concerns the total number of elementary flux vectors which may be huge because it combinatorially ...
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Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic pathways and have become an established tool for constraint-based modeling and metabolic network analysis. EFMs are characteristic (support-minimal) vectors of the flux cone that contains all feasible steady-state flux vectors of a given metabolic network. EFMs account for (homogeneous) linear constraints arising fro...
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The concept of Elementary Flux Modes (EFMs) has been of central importance in a number of studies involving the analysis of metabolism. In Provost and Bastin (2007) this concept is used to translate the metabolic networks of the different phases of CHO cell cultures into macroscopic bioreactions linking extracellular substrates to products. However, a critical issue concerns the calculation of ...
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Intrinsic hierarchical structure of metabolic networks has been recently revealed [1]. Particular hierarchical decompositions can even present a property of relative independence between its branches which has been shown to be of a biological relevance. Here we use this property for computational purposes. A recursive and parallelizable variant of the classical algorithm for computing extreme p...
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ژورنال
عنوان ژورنال: Automatica
سال: 2011
ISSN: 0005-1098
DOI: 10.1016/j.automatica.2011.01.011